Basic Information
ID: ALA4358574
Type: Binding
Description: Inhibition of BTK in human basophils assessed as reduction in anti-IgE mouse IgG1 antibody Le2-stimulated CD63 expression on basophil preincubated for 30 mins in presence of IgE antibody B11 followed by anti-IgE mouse IgG1 antibody Le2 stimulation and measured after 15 mins by flow cytometry
Format: BAO_0000019
Organism: Homo sapiens
Target: Tyrosine-protein kinase BTK(ALA5251)
Document: ALA4354855
Inhibition of BTK in human basophils assessed as reduction in anti-IgE mouse IgG1 antibody Le2-stimulated CD63 expression on basophil preincubated for 30 mins in presence of IgE antibody B11 followed by anti-IgE mouse IgG1 antibody Le2 stimulation and measured after 15 mins by flow cytometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4358574
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 440.51 | 4.22 | 4.22 |
| 465.52 | 3.31 | 3.31 |
| 454.49 | 2.75 | 2.75 |
| 429.52 | 4.35 | 4.35 |
| 370.43 | 2.13 | 2.13 |
| 507.54 | 4.47 | 4.47 |