Basic Information
ID: ALA4358945
Type: Binding
Description: Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabelled amino-butylidene incorporation in eIF5A using [3H]Spermidine trichloride as substrate after 90 to 120 mins in presence of eIF5A and 14 uM NAD+ by Topcount scintillation counting method
Format: BAO_0000019
Organism: Homo sapiens
Target: Deoxyhypusine synthase(ALA4415)
Document: ALA4354863
Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabelled amino-butylidene incorporation in eIF5A using [3H]Spermidine trichloride as substrate after 90 to 120 mins in presence of eIF5A and 14 uM NAD+ by Topcount scintillation counting method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4358945
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 172.28 | 0.38 | 0.38 |
| 286.33 | 4.57 | 4.57 |
| 328.44 | 4.27 | 4.27 |
| 276.30 | 4.17 | 4.17 |
| 335.39 | 3.73 | 3.73 |
| 317.37 | 4.51 | 4.51 |
| 292.38 | 4.72 | 4.72 |
| 292.38 | 4.72 | 4.72 |
| 294.40 | 4.20 | 4.20 |
| 293.37 | 4.11 | 4.11 |
| 326.81 | 5.29 | 5.29 |
| 292.36 | 4.63 | 4.63 |
| 371.26 | 5.40 | 5.40 |
| 236.27 | 3.42 | 3.42 |
| 371.26 | 5.40 | 5.40 |
| 418.26 | 5.24 | 5.24 |
| 307.40 | 5.11 | 5.11 |
| 371.26 | 5.40 | 5.40 |
| 293.37 | 4.11 | 4.11 |
| 308.38 | 3.73 | 3.73 |
| 348.47 | 5.93 | 5.93 |