Basic Information
ID: ALA4359943
Type: Binding
Description: Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase level preincubated for 1 hr followed by LPS stimulation and measured after 20 hrs by quanti-blue reagent based reporter assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Interleukin-1 receptor-associated kinase 4(ALA3778)
Document: ALA4359811
Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase level preincubated for 1 hr followed by LPS stimulation and measured after 20 hrs by quanti-blue reagent based reporter assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4359943
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 401.47 | 2.70 | 2.70 |
| 319.32 | 2.54 | 2.54 |
| 307.31 | 2.47 | 2.47 |
| 318.34 | 3.14 | 3.14 |
| 504.60 | 2.40 | 2.40 |
| 463.54 | 1.56 | 1.56 |
| 409.45 | 1.50 | 1.50 |
| 489.50 | 3.83 | 3.83 |
| 402.46 | 2.74 | 2.74 |
| 418.46 | 2.40 | 2.40 |
| 377.45 | 3.30 | 3.30 |
| 476.54 | 1.90 | 1.90 |
| 457.54 | 3.36 | 3.36 |
| 434.50 | 2.40 | 2.40 |
| 443.45 | 3.47 | 3.47 |
| 409.45 | 2.24 | 2.24 |
| 451.56 | 2.87 | 2.87 |
| 409.45 | 2.24 | 2.24 |
| 409.45 | 1.50 | 1.50 |
| 421.50 | 2.90 | 2.90 |
| 393.45 | 2.53 | 2.53 |
| 493.59 | 2.64 | 2.64 |
| 459.45 | 3.13 | 3.13 |
| 490.57 | 1.91 | 1.91 |
| 449.52 | 1.30 | 1.30 |
| 477.53 | 2.17 | 2.17 |
| 423.47 | 2.02 | 2.02 |
| 436.47 | 1.63 | 1.63 |
| 448.53 | 2.22 | 2.22 |
| 421.50 | 3.05 | 3.05 |
| 458.53 | 2.75 | 2.75 |
| 433.51 | 3.41 | 3.41 |
| 415.50 | 3.59 | 3.59 |
| 391.44 | 2.07 | 2.07 |
| 319.32 | 2.54 | 2.54 |
| 465.54 | 2.26 | 2.26 |
| 392.46 | 2.10 | 2.10 |
| 372.43 | 3.52 | 3.52 |
| 437.50 | 2.28 | 2.28 |
| 436.52 | 1.81 | 1.81 |