Basic Information
ID: ALA4360242
Type: Binding
Description: Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketoglutarate substrate and NADPH addition after 45 mins by diaphorase and resazurin dye based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4360242
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 392.86 | 3.21 | 3.21 |
| 323.33 | 3.16 | 3.16 |
| 468.94 | 3.38 | 3.38 |
| 324.77 | 3.37 | 3.37 |
| 339.78 | 3.67 | 3.67 |
| 350.81 | 3.86 | 3.86 |
| 384.23 | 3.78 | 3.78 |
| 338.80 | 3.93 | 3.93 |
| 385.81 | 3.03 | 3.03 |
| 352.83 | 4.10 | 4.10 |
| 366.81 | 3.08 | 3.08 |
| 426.90 | 3.61 | 3.61 |
| 299.76 | 3.50 | 3.50 |
| 369.81 | 3.68 | 3.68 |
| 378.74 | 4.08 | 4.08 |
| 308.38 | 3.77 | 3.77 |
| 355.79 | 3.02 | 3.02 |
| 395.85 | 3.90 | 3.90 |
| 377.75 | 4.68 | 4.68 |
| 373.46 | 4.56 | 4.56 |
| 323.78 | 3.34 | 3.34 |
| 468.94 | 3.38 | 3.38 |
| 369.81 | 3.68 | 3.68 |
| 463.93 | 4.29 | 4.29 |
| 393.75 | 4.56 | 4.56 |
| 353.81 | 4.06 | 4.06 |
| 339.79 | 3.32 | 3.32 |
| 341.80 | 3.15 | 3.15 |
| 324.77 | 3.37 | 3.37 |
| 327.75 | 3.80 | 3.80 |
| 353.81 | 4.23 | 4.23 |
| 446.89 | 4.65 | 4.65 |
| 446.89 | 4.65 | 4.65 |
| 309.76 | 3.67 | 3.67 |
| 373.33 | 4.04 | 4.04 |
| 305.34 | 3.02 | 3.02 |
| 452.94 | 4.15 | 4.15 |
| 361.45 | 4.32 | 4.32 |
| 350.81 | 3.98 | 3.98 |
| 310.74 | 3.06 | 3.06 |
| 332.37 | 2.83 | 2.83 |
| 373.78 | 3.16 | 3.16 |
| 413.87 | 3.81 | 3.81 |
| 376.42 | 2.74 | 2.74 |
| 369.85 | 3.63 | 3.63 |
| 354.80 | 3.63 | 3.63 |
| 396.84 | 2.79 | 2.79 |
| 452.94 | 4.15 | 4.15 |
| 323.78 | 3.97 | 3.97 |
| 319.36 | 3.33 | 3.33 |
| 309.76 | 3.67 | 3.67 |
| 362.39 | 2.43 | 2.43 |
| 369.81 | 3.68 | 3.68 |
| 325.76 | 3.37 | 3.37 |
| 339.78 | 3.67 | 3.67 |
| 425.88 | 3.81 | 3.81 |
| 338.80 | 3.93 | 3.93 |
| 354.80 | 3.63 | 3.63 |
| 382.81 | 2.78 | 2.78 |
| 348.37 | 2.12 | 2.12 |
| 466.93 | 3.68 | 3.68 |
| 362.39 | 2.43 | 2.43 |
| 466.97 | 4.54 | 4.54 |
| 335.36 | 3.03 | 3.03 |
| 338.80 | 3.93 | 3.93 |
| 346.39 | 2.73 | 2.73 |
| 354.80 | 3.63 | 3.63 |
| 368.85 | 4.31 | 4.31 |
| 462.90 | 4.00 | 4.00 |
| 345.19 | 3.71 | 3.71 |