Basic Information
ID: ALA4360246
Type: Binding
Description: Inhibition of human Myc-DDK-tagged IDH1 R132C mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketoglutarate substrate and NADPH addition after 45 mins by diaphorase and resazurin dye based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4360246
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 468.94 | 3.38 | 3.38 |
| 339.78 | 3.67 | 3.67 |
| 350.81 | 3.86 | 3.86 |
| 338.80 | 3.93 | 3.93 |
| 385.81 | 3.03 | 3.03 |
| 352.83 | 4.10 | 4.10 |
| 426.90 | 3.61 | 3.61 |
| 355.79 | 3.02 | 3.02 |
| 395.85 | 3.90 | 3.90 |
| 468.94 | 3.38 | 3.38 |
| 369.81 | 3.68 | 3.68 |
| 463.93 | 4.29 | 4.29 |
| 339.79 | 3.32 | 3.32 |
| 324.77 | 3.37 | 3.37 |
| 353.81 | 4.23 | 4.23 |
| 446.89 | 4.65 | 4.65 |
| 446.89 | 4.65 | 4.65 |
| 452.94 | 4.15 | 4.15 |
| 373.78 | 3.16 | 3.16 |
| 413.87 | 3.81 | 3.81 |
| 354.80 | 3.63 | 3.63 |
| 452.94 | 4.15 | 4.15 |
| 369.81 | 3.68 | 3.68 |
| 425.88 | 3.81 | 3.81 |
| 338.80 | 3.93 | 3.93 |
| 354.80 | 3.63 | 3.63 |
| 466.93 | 3.68 | 3.68 |
| 466.97 | 4.54 | 4.54 |
| 338.80 | 3.93 | 3.93 |
| 354.80 | 3.63 | 3.63 |
| 462.90 | 4.00 | 4.00 |