Basic Information
ID: ALA4361914
Type: Binding
Description: Reversal of P-gp-mediated multidrug resistance in human MCF7/Dox cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 12.5 uM after 48 hrs by MTT assay (Rvb = 51.19 +/- 0.95 microM)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4361914
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 298.34 | 3.62 | 3.62 |
| 438.57 | 4.45 | 4.45 |
| 352.43 | 3.01 | 3.01 |
| 442.51 | 4.84 | 4.84 |
| 382.46 | 4.82 | 4.82 |
| 450.58 | 4.57 | 4.57 |
| 382.46 | 3.06 | 3.06 |
| 382.46 | 4.82 | 4.82 |
| 352.43 | 4.81 | 4.81 |
| 386.88 | 5.47 | 5.47 |
| 382.46 | 3.02 | 3.02 |
| 396.49 | 3.28 | 3.28 |
| 397.43 | 4.72 | 4.72 |
| 468.55 | 4.36 | 4.36 |
| 368.43 | 2.72 | 2.72 |
| 370.42 | 4.95 | 4.95 |
| 436.55 | 4.22 | 4.22 |
| 395.50 | 4.88 | 4.88 |
| 420.43 | 5.83 | 5.83 |
| 532.59 | 4.29 | 4.29 |
| 536.67 | 5.87 | 5.87 |
| 369.42 | 3.14 | 3.14 |
| 468.55 | 4.36 | 4.36 |
| 386.88 | 5.47 | 5.47 |
| 536.67 | 5.87 | 5.87 |
| 424.54 | 4.06 | 4.06 |
| 442.51 | 4.84 | 4.84 |
| 410.51 | 3.67 | 3.67 |
| 420.43 | 5.83 | 5.83 |
| 436.55 | 4.22 | 4.22 |
| 437.54 | 4.65 | 4.65 |
| 370.42 | 4.95 | 4.95 |
| 368.43 | 2.72 | 2.72 |