Basic Information
ID: ALA4362496
Type: Binding
Description: Inhibition of N-terminal His-tagged human JAK2 catalytic domain (826 to 1132 resiudes) expressed in baculovirus expression system at 100 nM using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr in presence of ATP by mobility shift assay relative to control
Format: BAO_0000019
Organism: Homo sapiens
Target: Tyrosine-protein kinase JAK2(ALA2971)
Document: ALA4359878
Inhibition of N-terminal His-tagged human JAK2 catalytic domain (826 to 1132 resiudes) expressed in baculovirus expression system at 100 nM using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr in presence of ATP by mobility shift assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4362496
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 562.72 | 5.03 | 5.03 |
| 414.47 | 2.98 | 2.98 |
| 472.59 | 4.47 | 4.47 |
| 502.58 | 2.51 | 2.51 |
| 484.56 | 3.28 | 3.28 |
| 527.55 | 4.43 | 4.43 |
| 517.59 | 3.20 | 3.20 |
| 566.69 | 2.70 | 2.70 |
| 529.65 | 4.25 | 4.25 |
| 572.67 | 2.88 | 2.88 |
| 517.66 | 4.33 | 4.33 |
| 504.55 | 3.32 | 3.32 |
| 459.55 | 3.41 | 3.41 |
| 543.67 | 4.64 | 4.64 |
| 537.65 | 2.81 | 2.81 |
| 530.63 | 3.15 | 3.15 |
| 487.61 | 3.97 | 3.97 |
| 527.55 | 4.43 | 4.43 |
| 551.68 | 1.97 | 1.97 |
| 545.64 | 3.49 | 3.49 |
| 489.58 | 3.42 | 3.42 |
| 574.64 | 2.31 | 2.31 |
| 516.61 | 2.77 | 2.77 |
| 514.63 | 3.53 | 3.53 |
| 502.58 | 2.51 | 2.51 |
| 513.65 | 5.01 | 5.01 |
| 477.54 | 3.55 | 3.55 |
| 538.63 | 2.06 | 2.06 |
| 530.68 | 4.26 | 4.26 |
| 502.58 | 2.51 | 2.51 |
| 527.55 | 4.43 | 4.43 |
| 501.59 | 3.61 | 3.61 |
| 515.62 | 2.42 | 2.42 |
| 559.67 | 3.88 | 3.88 |
| 484.56 | 3.28 | 3.28 |
| 501.59 | 3.61 | 3.61 |
| 501.59 | 3.61 | 3.61 |
| 517.63 | 4.20 | 4.20 |