Basic Information
ID: ALA4364613
Type: Binding
Description: Inhibition of recombinant TOP1 (unknown origin) using 3'-[32P]-labeled 117 bp DNA oligonucleotide assessed as decrease in TOP1-mediated DNA cleavage incubated for 20 mins by PAGE analysis relative to 1 uM CPT
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA topoisomerase I(ALA1781)
Document: ALA4364246
Inhibition of recombinant TOP1 (unknown origin) using 3'-[32P]-labeled 117 bp DNA oligonucleotide assessed as decrease in TOP1-mediated DNA cleavage incubated for 20 mins by PAGE analysis relative to 1 uM CPT: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4364613
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 363.37 | 3.59 | 3.59 |
| 420.47 | 3.62 | 3.62 |
| 555.61 | 2.56 | 2.56 |
| 499.55 | 2.45 | 2.45 |
| 538.50 | 3.84 | 3.84 |
| 392.41 | 3.01 | 3.01 |
| 514.47 | 4.39 | 4.39 |
| 460.49 | 3.58 | 3.58 |
| 513.57 | 2.79 | 2.79 |
| 496.54 | 3.14 | 3.14 |
| 500.44 | 4.04 | 4.04 |
| 541.58 | 2.22 | 2.22 |
| 510.57 | 3.48 | 3.48 |
| 512.46 | 4.14 | 4.14 |
| 406.44 | 3.27 | 3.27 |
| 525.58 | 2.98 | 2.98 |
| 539.61 | 3.33 | 3.33 |