Basic Information
ID: ALA4367946
Type: Binding
Description: Inhibition of recombinant His-tagged BRAF V600E mutant (unknown origin) (444-723 residues) expressed in Escherichia coli BL21(DE3)-RIL using MEKK97R as substrate assessed as reduction in phosphorylation incubated for 20 mins by immunoblot assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Serine/threonine-protein kinase B-raf(ALA5145)
Document: ALA4364309
Inhibition of recombinant His-tagged BRAF V600E mutant (unknown origin) (444-723 residues) expressed in Escherichia coli BL21(DE3)-RIL using MEKK97R as substrate assessed as reduction in phosphorylation incubated for 20 mins by immunoblot assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4367946
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 489.93 | 5.54 | 5.54 |
| 488.48 | 5.09 | 5.09 |
| 501.52 | 6.01 | 6.01 |
| 453.94 | 5.33 | 5.33 |
| 521.93 | 6.35 | 6.35 |
| 487.49 | 5.53 | 5.53 |
| 487.49 | 5.70 | 5.70 |
| 501.52 | 6.01 | 6.01 |
| 488.47 | 5.75 | 5.75 |
| 567.58 | 6.19 | 6.19 |
| 486.50 | 6.30 | 6.30 |
| 473.46 | 5.14 | 5.14 |
| 453.94 | 5.08 | 5.08 |