Basic Information
ID: ALA4367978
Type: Binding
Description: Positive allosteric modulator activity at rat alpha1beta3 GABA-A receptor expressed in Xenopus laevis oocytes assessed as increase in GABA-induced chloride current at 10 uM co-applied with GABA at concentration of EC3-5 at -60 mV holding potential by two-microelectrode voltage clamp method relative to control
Organism: Rattus norvegicus
Activity Charts
Bioactivity
Activity Types for Assay ALA4367978
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 325.76 | 3.48 | 3.48 |
| 321.34 | 2.84 | 2.84 |
| 329.74 | 4.94 | 4.94 |
| 325.32 | 4.30 | 4.30 |
| 309.33 | 4.60 | 4.60 |
| 305.34 | 3.14 | 3.14 |
| 313.74 | 5.24 | 5.24 |
| 309.76 | 3.78 | 3.78 |