Basic Information
ID: ALA4370819
Type: Binding
Description: Inhibition of Leucyl-tRNA synthetase-mediated mTORC1 signaling activation in human HEK293 cells assessed as reduction in leucine-induced S6K phosphorylation at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4370819
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 459.49 | -2.22 | -2.22 |
| 117.19 | 0.35 | 0.35 |
| 586.37 | -1.58 | -1.58 |
| 478.92 | -0.94 | -0.94 |
| 476.47 | -3.22 | -3.22 |
| 482.48 | -1.43 | -1.43 |
| 460.47 | -2.19 | -2.19 |
| 444.47 | -1.16 | -1.16 |
| 460.47 | -2.19 | -2.19 |
| 460.47 | -2.19 | -2.19 |
| 602.36 | -2.61 | -2.61 |
| 622.40 | -0.82 | -0.82 |
| 473.51 | -1.96 | -1.96 |
| 501.48 | -2.46 | -2.46 |
| 496.51 | -1.42 | -1.42 |
| 492.94 | -0.48 | -0.48 |
| 502.55 | -0.42 | -0.42 |
| 494.91 | -1.53 | -1.53 |
| 476.47 | -3.22 | -3.22 |
| 474.45 | -3.46 | -3.46 |
| 477.45 | -3.51 | -3.51 |
| 608.38 | -0.83 | -0.83 |
| 474.45 | -3.46 | -3.46 |
| 458.50 | -2.25 | -2.25 |
| 504.52 | -1.91 | -1.91 |
| 477.52 | -1.54 | -1.54 |
| 538.97 | -1.26 | -1.26 |
| 490.50 | -2.76 | -2.76 |
| 499.46 | -2.71 | -2.71 |
| 442.45 | -1.38 | -1.38 |
| 524.94 | -1.91 | -1.91 |
| 488.52 | -1.07 | -1.07 |
| 461.45 | -2.48 | -2.48 |
| 444.47 | -1.16 | -1.16 |
| 513.36 | -0.29 | -0.29 |
| 480.46 | -1.68 | -1.68 |
| 460.47 | -2.19 | -2.19 |
| 443.49 | -1.19 | -1.19 |
| 460.47 | -2.19 | -2.19 |
| 476.54 | -1.25 | -1.25 |
| 476.47 | -3.22 | -3.22 |
| 474.50 | -1.53 | -1.53 |
| 490.50 | -2.56 | -2.56 |
| 460.47 | -2.19 | -2.19 |
| 600.35 | -2.86 | -2.86 |
| 475.44 | -3.75 | -3.75 |
| 461.45 | -2.48 | -2.48 |
| 496.51 | -1.26 | -1.26 |