Basic Information
ID: ALA4371733
Type: Binding
Description: Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as residual binding at 1 uM preincubated for 4 hrs followed by NO711 addition and measured after 40 mins by LC-ESI-MS/MS analysis relative to control
Format: BAO_0000219
Organism: Mus musculus
Cell type: HEK293
Target: GABA transporter 1(ALA5445)
Document: ALA4371014
Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as residual binding at 1 uM preincubated for 4 hrs followed by NO711 addition and measured after 40 mins by LC-ESI-MS/MS analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4371733
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 198.22 | 3.29 | 3.29 |
| 112.15 | 1.56 | 1.56 |
| 182.22 | 3.17 | 3.17 |
| 136.15 | 1.51 | 1.51 |
| 151.12 | 1.41 | 1.41 |
| 96.08 | 1.09 | 1.09 |
| 206.63 | 3.41 | 3.41 |
| 182.17 | 1.22 | 1.22 |
| 136.15 | 1.51 | 1.51 |
| 162.21 | 2.71 | 2.71 |
| 251.62 | 3.32 | 3.32 |
| 157.17 | 2.05 | 2.05 |
| 256.18 | 3.66 | 3.66 |
| 157.17 | 2.05 | 2.05 |
| 95.10 | 0.83 | 0.83 |
| 218.20 | 3.44 | 3.44 |
| 218.20 | 3.44 | 3.44 |
| 218.20 | 3.44 | 3.44 |
| 218.20 | 3.44 | 3.44 |
| 230.24 | 3.31 | 3.31 |
| 230.24 | 3.31 | 3.31 |
| 230.24 | 3.31 | 3.31 |
| 174.98 | 1.85 | 1.85 |
| 188.25 | 3.23 | 3.23 |
| 216.67 | 3.82 | 3.82 |
| 205.64 | 3.01 | 3.01 |
| 177.23 | 2.35 | 2.35 |
| 200.21 | 3.31 | 3.31 |
| 171.20 | 2.29 | 2.29 |
| 367.47 | 2.38 | 2.38 |
| 202.28 | 3.54 | 3.54 |
| 240.18 | 3.78 | 3.78 |
| 394.40 | 2.73 | 2.73 |
| 224.23 | 3.51 | 3.51 |
| 188.25 | 3.23 | 3.23 |
| 206.24 | 3.37 | 3.37 |
| 230.29 | 2.58 | 2.58 |
| 188.25 | 3.23 | 3.23 |
| 184.20 | 1.96 | 1.96 |
| 234.26 | 3.11 | 3.11 |
| 171.20 | 2.49 | 2.49 |
| 324.24 | 5.27 | 5.27 |
| 222.70 | 3.88 | 3.88 |
| 183.21 | 2.56 | 2.56 |
| 202.28 | 3.54 | 3.54 |
| 258.17 | 3.92 | 3.92 |
| 373.40 | 2.87 | 2.87 |
| 190.23 | 2.02 | 2.02 |
| 206.63 | 3.41 | 3.41 |
| 353.42 | 2.71 | 2.71 |
| 191.23 | 1.28 | 1.28 |
| 199.21 | 1.54 | 1.54 |
| 239.20 | 3.31 | 3.31 |
| 274.62 | 4.43 | 4.43 |
| 251.08 | 3.52 | 3.52 |
| 251.08 | 3.52 | 3.52 |
| 219.67 | 3.16 | 3.16 |
| 209.23 | 1.37 | 1.37 |
| 234.26 | 3.11 | 3.11 |
| 162.15 | 1.48 | 1.48 |
| 326.40 | 1.71 | 1.71 |
| 308.18 | 4.80 | 4.80 |
| 222.70 | 3.88 | 3.88 |
| 108.10 | 0.29 | 0.29 |
| 222.70 | 3.88 | 3.88 |
| 188.25 | 3.23 | 3.23 |
| 411.38 | 3.08 | 3.08 |
| 377.54 | 3.33 | 3.33 |
| 291.35 | 0.93 | 0.93 |
| 257.14 | 4.53 | 4.53 |
| 206.63 | 3.41 | 3.41 |
| 212.27 | 2.96 | 2.96 |
| 221.98 | 1.70 | 1.70 |
| 338.41 | 1.98 | 1.98 |
| 202.19 | 2.10 | 2.10 |
| 196.25 | 3.47 | 3.47 |
| 332.43 | 1.77 | 1.77 |
| 213.24 | 1.90 | 1.90 |
| 216.31 | 3.84 | 3.84 |
| 373.40 | 2.87 | 2.87 |
| 172.18 | 2.76 | 2.76 |
| 202.28 | 3.54 | 3.54 |
| 224.62 | 3.55 | 3.55 |
| 174.16 | 1.55 | 1.55 |
| 222.33 | 3.91 | 3.91 |
| 174.98 | 1.85 | 1.85 |
| 312.37 | 1.47 | 1.47 |
| 241.07 | 4.07 | 4.07 |
| 312.37 | 1.47 | 1.47 |
| 240.18 | 3.78 | 3.78 |
| 222.24 | 3.91 | 3.91 |
| 429.83 | 3.85 | 3.85 |
| 274.62 | 4.43 | 4.43 |
| 373.40 | 2.87 | 2.87 |
| 343.45 | 2.65 | 2.65 |
| 373.40 | 2.87 | 2.87 |
| 306.32 | 0.83 | 0.83 |
| 317.41 | 2.14 | 2.14 |
| 185.19 | 1.35 | 1.35 |
| 291.35 | 0.93 | 0.93 |