Basic Information
ID: ALA4371950
Type: ADME
Description: Intrinsic metabolic stability in human liver microsomes assessed as metabolic turnover rate per mg protein at 1 uM preincubated for 5 mins followed by NADPH cofactor addition and measured after 30 mins by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: ADMET(ALA612558)
Document: ALA4371025
Intrinsic metabolic stability in human liver microsomes assessed as metabolic turnover rate per mg protein at 1 uM preincubated for 5 mins followed by NADPH cofactor addition and measured after 30 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4371950
Drug metabolism
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 519.53 | 6.23 | 6.23 |
| 469.47 | 5.02 | 5.02 |
| 492.50 | 6.53 | 6.53 |
| 468.48 | 5.63 | 5.63 |
| 520.52 | 5.62 | 5.62 |
| 482.51 | 5.93 | 5.93 |
| 482.51 | 5.93 | 5.93 |
| 487.91 | 6.70 | 6.70 |
| 442.44 | 5.37 | 5.37 |
| 468.48 | 5.63 | 5.63 |
| 453.46 | 6.04 | 6.04 |
| 502.92 | 6.28 | 6.28 |
| 454.45 | 5.44 | 5.44 |
| 469.47 | 5.02 | 5.02 |
| 453.46 | 6.04 | 6.04 |