Basic Information
ID: ALA4372487
Type: Binding
Description: Displacement of biotin-labeled geldanamycin from His-tagged HSP90alpha NTD (unknown origin) preincubated for 2 hrs followed by biotin-labeled geldanamycin addition and measured after 1 hr by AlphaScreen assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Heat shock protein HSP 90-alpha(ALA3880)
Document: ALA4371046
Displacement of biotin-labeled geldanamycin from His-tagged HSP90alpha NTD (unknown origin) preincubated for 2 hrs followed by biotin-labeled geldanamycin addition and measured after 1 hr by AlphaScreen assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4372487
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 520.64 | 5.57 | 5.57 |
| 520.64 | 5.57 | 5.57 |
| 520.64 | 5.57 | 5.57 |
| 470.58 | 4.42 | 4.42 |
| 500.60 | 4.43 | 4.43 |
| 523.64 | 4.91 | 4.91 |
| 500.60 | 4.43 | 4.43 |
| 524.67 | 5.30 | 5.30 |
| 459.55 | 3.54 | 3.54 |
| 535.65 | 5.21 | 5.21 |
| 440.51 | 3.54 | 3.54 |
| 454.54 | 3.79 | 3.79 |
| 455.53 | 3.27 | 3.27 |
| 537.63 | 4.00 | 4.00 |
| 565.68 | 5.22 | 5.22 |
| 627.75 | 7.00 | 7.00 |
| 519.65 | 6.18 | 6.18 |
| 475.62 | 5.09 | 5.09 |
| 491.60 | 5.36 | 5.36 |
| 525.61 | 4.80 | 4.80 |
| 539.64 | 3.94 | 3.94 |
| 536.64 | 4.61 | 4.61 |
| 469.59 | 5.03 | 5.03 |
| 455.53 | 3.27 | 3.27 |
| 426.48 | 3.23 | 3.23 |
| 476.58 | 5.66 | 5.66 |
| 519.65 | 6.18 | 6.18 |
| 525.62 | 3.73 | 3.73 |
| 490.61 | 5.97 | 5.97 |
| 477.57 | 5.06 | 5.06 |
| 536.64 | 4.61 | 4.61 |
| 459.55 | 4.62 | 4.62 |
| 541.68 | 5.27 | 5.27 |