Basic Information
ID: ALA4373220
Type: ADME
Description: Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp method
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Sodium channel protein type V alpha subunit(ALA1980)
Document: ALA4371076
Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4373220
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 422.43 | 4.14 | 4.14 |
| 435.93 | 3.62 | 3.62 |
| 436.92 | 3.01 | 3.01 |
| 459.96 | 3.90 | 3.90 |
| 445.52 | 3.64 | 3.64 |
| 440.42 | 4.23 | 4.23 |
| 414.38 | 3.69 | 3.69 |
| 449.96 | 4.01 | 4.01 |
| 463.99 | 4.66 | 4.66 |
| 494.44 | 5.26 | 5.26 |
| 402.48 | 2.36 | 2.36 |
| 342.42 | 2.84 | 2.84 |
| 404.44 | 4.00 | 4.00 |
| 464.98 | 3.46 | 3.46 |
| 504.05 | 5.27 | 5.27 |
| 479.96 | 4.29 | 4.29 |
| 463.99 | 4.40 | 4.40 |
| 401.49 | 2.96 | 2.96 |
| 415.37 | 3.09 | 3.09 |
| 430.83 | 4.21 | 4.21 |
| 461.85 | 3.52 | 3.52 |
| 328.39 | 2.53 | 2.53 |
| 420.47 | 2.50 | 2.50 |
| 457.55 | 3.51 | 3.51 |
| 425.43 | 3.40 | 3.40 |
| 478.01 | 4.74 | 4.74 |
| 446.50 | 3.03 | 3.03 |
| 505.04 | 4.39 | 4.39 |
| 450.36 | 4.44 | 4.44 |
| 400.50 | 3.57 | 3.57 |
| 443.86 | 3.23 | 3.23 |
| 478.01 | 4.79 | 4.79 |
| 384.50 | 3.73 | 3.73 |
| 397.38 | 2.95 | 2.95 |
| 364.37 | 2.81 | 2.81 |
| 453.92 | 3.76 | 3.76 |
| 396.39 | 3.61 | 3.61 |
| 433.92 | 3.37 | 3.37 |
| 441.41 | 3.62 | 3.62 |
| 422.43 | 4.09 | 4.09 |
| 431.51 | 2.97 | 2.97 |
| 356.45 | 3.10 | 3.10 |
| 419.48 | 3.10 | 3.10 |
| 412.39 | 3.43 | 3.43 |
| 396.39 | 3.55 | 3.55 |
| 464.49 | 5.04 | 5.04 |
| 461.97 | 4.15 | 4.15 |
| 378.40 | 3.47 | 3.47 |
| 356.45 | 3.10 | 3.10 |
| 396.39 | 3.55 | 3.55 |
| 329.38 | 1.93 | 1.93 |
| 426.50 | 2.84 | 2.84 |
| 342.42 | 2.84 | 2.84 |
| 462.96 | 3.55 | 3.55 |
| 451.93 | 2.73 | 2.73 |