Assay Report Card

Basic Information

ID: ALA4374936

Type: Binding

Description: Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl coenzyme A and N-terminal histone H4 peptide (sequence SGRGKGGKGLGKGGAKRHRKV-GGK-biotin) as substrate incubated for 60 mins by Alpha screen technology

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4374936

IC50

Total(72)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
312.30	1.59	1.59
386.86	3.63	3.63
356.40	2.47	2.47
308.33	1.76	1.76
312.30	1.59	1.59
344.37	2.60	2.60
360.44	0.72	0.72
377.43	2.85	2.85
328.75	2.10	2.10
370.41	3.12	3.12
336.39	2.57	2.57
362.30	2.47	2.47
324.33	1.46	1.46
370.41	3.12	3.12
372.42	3.16	3.16
386.86	3.63	3.63
362.36	2.74	2.74
360.82	3.12	3.12
384.43	3.42	3.42
353.40	2.37	2.37
370.40	3.12	3.12
324.33	1.46	1.46
309.32	1.03	1.03
308.33	1.76	1.76
353.40	2.37	2.37
404.85	3.77	3.77
353.40	2.37	2.37
377.43	2.85	2.85
373.20	2.21	2.21
324.33	1.46	1.46
344.37	2.60	2.60
319.32	1.32	1.32
410.37	3.36	3.36
312.30	1.59	1.59
378.81	3.26	3.26
354.39	1.77	1.77
368.46	3.59	3.59
370.41	3.12	3.12
324.33	1.46	1.46
337.33	0.55	0.55
328.75	2.10	2.10
412.36	3.62	3.62
382.44	2.99	2.99
382.44	2.99	2.99
353.40	2.37	2.37
358.39	2.91	2.91
394.37	3.48	3.48
326.38	2.46	2.46
319.32	1.32	1.32
309.32	1.03	1.03
371.39	2.51	2.51
294.31	1.45	1.45
358.44	3.04	3.04
382.44	2.99	2.99
386.86	3.63	3.63
358.44	3.04	3.04
322.36	2.01	2.01
308.33	1.76	1.76
276.32	1.31	1.31
340.40	2.77	2.77
352.42	2.98	2.98
312.30	1.59	1.59
340.40	2.77	2.77
308.33	1.76	1.76
373.20	2.21	2.21
358.39	2.91	2.91
370.41	3.12	3.12
402.48	4.13	4.13
362.30	2.47	2.47
351.39	2.33	2.33
342.38	2.17	2.17
319.32	1.32	1.32