Basic Information
ID: ALA4375055
Type: ADME
Description: Antagonist activity at beta1 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Beta-1 adrenergic receptor(ALA213)
Document: ALA4373696
Antagonist activity at beta1 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes assessed as inhibition of isoproterenol-induced cAMP production preincubated for 15 mins followed by isoproterenol addition and measured after 30 mins by TR-FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4375055
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 249.35 | 2.15 | 2.15 |
| 520.67 | 2.64 | 2.64 |
| 249.35 | 2.15 | 2.15 |
| 249.35 | 2.15 | 2.15 |
| 556.83 | 6.07 | 6.07 |
| 584.89 | 6.85 | 6.85 |
| 621.79 | 1.73 | 1.73 |
| 558.76 | 3.03 | 3.03 |
| 586.77 | 1.96 | 1.96 |
| 600.80 | 2.35 | 2.35 |
| 649.84 | 2.12 | 2.12 |
| 614.87 | 4.59 | 4.59 |
| 642.88 | 3.52 | 3.52 |
| 500.72 | 4.51 | 4.51 |
| 558.72 | 1.18 | 1.18 |
| 677.90 | 2.90 | 2.90 |
| 528.78 | 5.29 | 5.29 |
| 593.73 | 1.61 | 1.61 |
| 614.83 | 2.74 | 2.74 |
| 564.72 | 2.65 | 2.65 |
| 586.82 | 3.81 | 3.81 |
| 530.71 | 2.25 | 2.25 |
| 628.86 | 3.13 | 3.13 |
| 614.83 | 2.74 | 2.74 |