Basic Information
ID: ALA4375167
Type: Binding
Description: Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate in presence of 19 uM NAD+ and PSAT1 by diaphorase based luminescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4375167
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 424.53 | 3.12 | 3.12 |
| 349.39 | 3.28 | 3.28 |
| 483.37 | 4.14 | 4.14 |
| 386.84 | 4.03 | 4.03 |
| 405.28 | 4.98 | 4.98 |
| 388.47 | 3.70 | 3.70 |
| 328.80 | 3.30 | 3.30 |
| 398.49 | 2.95 | 2.95 |
| 406.82 | 4.96 | 4.96 |
| 291.35 | 3.02 | 3.02 |
| 432.48 | 3.16 | 3.16 |
| 356.81 | 4.02 | 4.02 |
| 412.52 | 2.97 | 2.97 |
| 341.80 | 2.79 | 2.79 |
| 319.41 | 3.89 | 3.89 |
| 327.81 | 3.26 | 3.26 |
| 372.42 | 4.52 | 4.52 |
| 305.38 | 3.58 | 3.58 |
| 427.48 | 2.44 | 2.44 |
| 403.44 | 2.63 | 2.63 |
| 404.83 | 4.17 | 4.17 |
| 320.40 | 3.16 | 3.16 |
| 448.93 | 3.49 | 3.49 |
| 391.25 | 4.67 | 4.67 |
| 342.83 | 3.68 | 3.68 |
| 384.86 | 4.58 | 4.58 |
| 406.49 | 2.12 | 2.12 |
| 396.80 | 4.23 | 4.23 |
| 370.84 | 4.33 | 4.33 |
| 335.36 | 2.72 | 2.72 |
| 362.44 | 2.88 | 2.88 |
| 376.46 | 2.91 | 2.91 |
| 349.39 | 3.28 | 3.28 |
| 350.38 | 3.49 | 3.49 |
| 384.46 | 2.23 | 2.23 |
| 440.81 | 4.92 | 4.92 |
| 456.52 | 2.43 | 2.43 |
| 386.45 | 4.83 | 4.83 |
| 363.42 | 3.45 | 3.45 |
| 348.41 | 2.68 | 2.68 |
| 426.50 | 2.27 | 2.27 |
| 342.83 | 3.95 | 3.95 |
| 335.41 | 3.59 | 3.59 |
| 374.49 | 4.18 | 4.18 |
| 396.80 | 4.23 | 4.23 |
| 390.49 | 3.15 | 3.15 |
| 330.39 | 3.45 | 3.45 |
| 435.71 | 4.78 | 4.78 |
| 363.42 | 3.21 | 3.21 |
| 322.36 | 3.37 | 3.37 |
| 383.47 | 2.98 | 2.98 |
| 426.50 | 2.40 | 2.40 |
| 305.38 | 3.58 | 3.58 |
| 342.83 | 3.68 | 3.68 |
| 383.46 | 4.04 | 4.04 |
| 335.41 | 3.07 | 3.07 |
| 342.78 | 3.39 | 3.39 |
| 426.50 | 2.40 | 2.40 |
| 342.83 | 3.69 | 3.69 |
| 370.84 | 4.33 | 4.33 |