Basic Information
ID: ALA4375168
Type: Binding
Description: Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate in presence of 250 uM NAD+ and PSAT1 by diaphorase based luminescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4375168
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.37 | 4.14 | 4.14 |
| 386.84 | 4.03 | 4.03 |
| 405.28 | 4.98 | 4.98 |
| 406.82 | 4.96 | 4.96 |
| 356.81 | 4.02 | 4.02 |
| 372.42 | 4.52 | 4.52 |
| 404.83 | 4.17 | 4.17 |
| 448.93 | 3.49 | 3.49 |
| 391.25 | 4.67 | 4.67 |
| 384.86 | 4.58 | 4.58 |
| 370.84 | 4.33 | 4.33 |
| 440.81 | 4.92 | 4.92 |
| 499.37 | 3.12 | 3.12 |
| 386.45 | 4.83 | 4.83 |
| 435.71 | 4.78 | 4.78 |
| 370.84 | 4.33 | 4.33 |