Basic Information
ID: ALA4376103
Type: Binding
Description: Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay
Organism: Homo sapiens
Cell type: Sf21
Activity Charts
Bioactivity
Activity Types for Assay ALA4376103
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 334.45 | 2.59 | 2.59 |
| 384.49 | 4.39 | 4.39 |
| 336.40 | 3.62 | 3.62 |
| 309.39 | 4.50 | 4.50 |
| 468.63 | 3.96 | 3.96 |
| 388.54 | 3.53 | 3.53 |
| 424.51 | 2.99 | 2.99 |
| 492.62 | 3.87 | 3.87 |
| 362.50 | 3.00 | 3.00 |
| 394.48 | 4.15 | 4.15 |
| 477.61 | 4.48 | 4.48 |
| 416.59 | 4.17 | 4.17 |
| 509.66 | 3.60 | 3.60 |
| 427.48 | 3.55 | 3.55 |
| 400.52 | 4.01 | 4.01 |
| 426.49 | 4.15 | 4.15 |
| 491.64 | 4.48 | 4.48 |
| 408.50 | 3.14 | 3.14 |
| 386.50 | 3.76 | 3.76 |
| 408.50 | 4.02 | 4.02 |
| 371.48 | 3.23 | 3.23 |
| 425.56 | 3.58 | 3.58 |
| 424.57 | 4.18 | 4.18 |
| 338.39 | 2.80 | 2.80 |
| 416.59 | 4.31 | 4.31 |
| 376.53 | 3.39 | 3.39 |
| 409.49 | 3.41 | 3.41 |
| 331.42 | 2.52 | 2.52 |
| 385.51 | 3.62 | 3.62 |
| 443.94 | 4.06 | 4.06 |
| 360.46 | 3.22 | 3.22 |
| 343.43 | 2.45 | 2.45 |
| 407.51 | 3.74 | 3.74 |
| 401.51 | 2.57 | 2.57 |
| 425.56 | 3.58 | 3.58 |
| 424.51 | 2.99 | 2.99 |
| 318.38 | 2.42 | 2.42 |
| 442.95 | 4.67 | 4.67 |
| 346.43 | 2.83 | 2.83 |
| 357.45 | 2.84 | 2.84 |
| 442.95 | 4.67 | 4.67 |
| 390.55 | 3.64 | 3.64 |
| 358.44 | 2.98 | 2.98 |
| 442.56 | 4.32 | 4.32 |
| 345.44 | 2.69 | 2.69 |
| 442.56 | 4.32 | 4.32 |
| 430.55 | 1.72 | 1.72 |
| 466.59 | 3.82 | 3.82 |
| 400.52 | 4.15 | 4.15 |
| 332.40 | 2.44 | 2.44 |
| 385.42 | 3.13 | 3.13 |
| 438.53 | 3.03 | 3.03 |
| 443.55 | 2.83 | 2.83 |
| 409.49 | 3.41 | 3.41 |
| 429.57 | 3.30 | 3.30 |
| 401.49 | 3.60 | 3.60 |
| 374.51 | 3.14 | 3.14 |
| 374.49 | 3.47 | 3.47 |
| 509.63 | 4.62 | 4.62 |
| 402.56 | 3.92 | 3.92 |
| 426.49 | 4.15 | 4.15 |
| 459.02 | 4.83 | 4.83 |
| 372.47 | 3.37 | 3.37 |
| 348.47 | 2.61 | 2.61 |
| 317.39 | 1.96 | 1.96 |
| 415.54 | 2.91 | 2.91 |
| 431.54 | 2.15 | 2.15 |
| 459.02 | 4.83 | 4.83 |