Basic Information
ID: ALA4376261
Type: Binding
Description: Inhibition of Pseudomonas aeruginosa tRNA (guanine(37)-N1)-methyltransferase (Leu5 to Asp25 residues) expressed in Escherichia coli BL21 (DE3) Rosetta T1R cells assessed as reduction in S-adenosyl-L-homocysteine production preincubated for 15 mins followed by 1.5 uM of tRNALeu(CAG) substrate and SAM addition and measured after 45 mins by MTase-Glo assay
Organism: Pseudomonas aeruginosa
Activity Charts
Bioactivity
Activity Types for Assay ALA4376261
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 397.50 | 1.84 | 1.84 |
| 424.57 | 4.07 | 4.07 |
| 464.04 | 2.91 | 2.91 |
| 370.48 | 2.76 | 2.76 |
| 482.01 | 1.00 | 1.00 |
| 580.62 | 1.63 | 1.63 |
| 421.95 | 1.74 | 1.74 |
| 488.66 | 5.50 | 5.50 |
| 448.59 | 3.97 | 3.97 |
| 454.64 | 5.10 | 5.10 |
| 557.72 | 7.59 | 7.59 |
| 430.53 | 2.06 | 2.06 |
| 384.51 | 3.19 | 3.19 |
| 382.49 | 2.90 | 2.90 |
| 370.48 | 2.80 | 2.80 |
| 454.64 | 5.14 | 5.14 |
| 426.59 | 4.36 | 4.36 |
| 432.55 | 3.94 | 3.94 |
| 435.98 | 2.13 | 2.13 |
| 482.69 | 5.93 | 5.93 |
| 467.46 | 0.95 | 0.95 |
| 402.48 | 1.01 | 1.01 |
| 516.71 | 6.28 | 6.28 |
| 404.50 | 3.20 | 3.20 |
| 396.52 | 3.34 | 3.34 |
| 384.46 | 1.75 | 1.75 |