Basic Information
ID: ALA4376262
Type: Binding
Description: Inhibition of Pseudomonas aeruginosa tRNA (guanine(37)-N1)-methyltransferase (Leu5 to Asp25 residues) expressed in Escherichia coli BL21 Rosetta (DE3) assessed as reduction in S-adenosyl-L-homocysteine production preincubated for 15 mins followed by 4.5 uM of tRNALeu(CAG) substrate and SAM addition and measured after 45 mins by MTase-Glo assay
Organism: Pseudomonas aeruginosa
Activity Charts
Bioactivity
Activity Types for Assay ALA4376262
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 397.50 | 1.84 | 1.84 |
| 426.59 | 4.36 | 4.36 |