Basic Information
ID: ALA4377381
Type: Binding
Description: Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by stimulation with IFN-alpha for 15 mins by fluorescence analysis
Organism: Homo sapiens
Tissue: Blood
Activity Charts
Bioactivity
Activity Types for Assay ALA4377381
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 462.49 | 3.58 | 3.58 |
| 425.47 | 1.73 | 1.73 |
| 468.49 | 2.50 | 2.50 |
| 452.49 | 3.53 | 3.53 |
| 463.47 | 4.14 | 4.14 |
| 462.49 | 3.87 | 3.87 |
| 438.46 | 3.14 | 3.14 |
| 455.48 | 3.00 | 3.00 |
| 395.44 | 1.72 | 1.72 |
| 515.55 | 4.10 | 4.10 |
| 421.46 | 2.34 | 2.34 |
| 424.44 | 2.83 | 2.83 |
| 478.53 | 3.92 | 3.92 |
| 411.39 | 3.17 | 3.17 |
| 424.44 | 2.83 | 2.83 |
| 424.44 | 2.88 | 2.88 |
| 394.41 | 2.82 | 2.82 |
| 449.45 | 3.83 | 3.83 |
| 462.49 | 3.58 | 3.58 |
| 498.47 | 4.15 | 4.15 |
| 462.49 | 3.58 | 3.58 |
| 461.50 | 4.18 | 4.18 |
| 424.48 | 2.34 | 2.34 |
| 461.50 | 4.18 | 4.18 |
| 448.46 | 3.56 | 3.56 |
| 452.49 | 3.48 | 3.48 |
| 537.60 | 2.84 | 2.84 |
| 459.51 | 3.14 | 3.14 |
| 410.41 | 2.57 | 2.57 |
| 410.41 | 2.57 | 2.57 |
| 392.39 | 3.34 | 3.34 |