Basic Information
ID: ALA4380044
Type: Binding
Description: Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition of N-terminal biotinylated co-activator SRC1 box2 peptide recruitment measured after 30 mins in presence of 0.25 uM RORgamma agonist cholesterol by TR-FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4380044
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 780.95 | 2.22 | 2.22 |
| 444.80 | 5.76 | 5.76 |
| 431.30 | 5.77 | 5.77 |
| 461.83 | 6.32 | 6.32 |