Basic Information
ID: ALA4380185
Type: Binding
Description: Inhibition of wild type human NET expressed in HEK293 cells assessed as inhibition of [3H]-MPP+ reuptake preincubated for 5 mins followed by [3H]MPP+ addition and measured after 3 mins by liquid scintillation counting analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Norepinephrine transporter(ALA222)
Document: ALA4376858
Inhibition of wild type human NET expressed in HEK293 cells assessed as inhibition of [3H]-MPP+ reuptake preincubated for 5 mins followed by [3H]MPP+ addition and measured after 3 mins by liquid scintillation counting analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4380185
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 273.36 | 2.01 | 2.01 |
| 341.50 | 4.80 | 4.80 |
| 347.89 | 4.83 | 4.83 |
| 341.50 | 4.80 | 4.80 |
| 311.43 | 4.16 | 4.16 |
| 392.34 | 4.94 | 4.94 |
| 353.51 | 5.06 | 5.06 |
| 382.34 | 5.49 | 5.49 |
| 331.44 | 4.32 | 4.32 |
| 349.43 | 4.46 | 4.46 |
| 392.34 | 4.94 | 4.94 |
| 422.40 | 6.37 | 6.37 |
| 341.50 | 4.80 | 4.80 |
| 343.47 | 4.19 | 4.19 |
| 447.67 | 6.65 | 6.65 |
| 392.34 | 4.94 | 4.94 |
| 381.44 | 5.20 | 5.20 |
| 355.53 | 5.13 | 5.13 |
| 382.34 | 5.49 | 5.49 |
| 327.47 | 4.49 | 4.49 |
| 341.50 | 4.53 | 4.53 |
| 373.50 | 4.20 | 4.20 |
| 382.34 | 5.49 | 5.49 |
| 327.47 | 4.49 | 4.49 |
| 369.56 | 5.48 | 5.48 |
| 341.50 | 4.80 | 4.80 |
| 347.89 | 4.83 | 4.83 |
| 343.47 | 4.19 | 4.19 |
| 349.43 | 4.46 | 4.46 |
| 341.50 | 4.74 | 4.74 |
| 347.89 | 4.83 | 4.83 |
| 381.44 | 5.20 | 5.20 |
| 392.34 | 4.94 | 4.94 |
| 355.53 | 5.30 | 5.30 |
| 341.50 | 4.80 | 4.80 |
| 347.89 | 4.83 | 4.83 |
| 349.43 | 4.46 | 4.46 |
| 369.56 | 5.52 | 5.52 |
| 349.43 | 4.46 | 4.46 |
| 392.34 | 4.94 | 4.94 |
| 311.48 | 5.47 | 5.47 |
| 347.89 | 4.83 | 4.83 |
| 331.44 | 4.32 | 4.32 |
| 327.47 | 4.49 | 4.49 |
| 331.44 | 4.32 | 4.32 |
| 327.47 | 4.49 | 4.49 |
| 381.57 | 5.68 | 5.68 |
| 341.50 | 4.80 | 4.80 |
| 381.44 | 5.20 | 5.20 |
| 381.44 | 5.20 | 5.20 |
| 392.34 | 4.94 | 4.94 |
| 392.34 | 4.94 | 4.94 |
| 327.47 | 4.49 | 4.49 |
| 331.44 | 4.32 | 4.32 |
| 343.47 | 4.19 | 4.19 |
| 343.47 | 4.19 | 4.19 |
| 413.56 | 5.08 | 5.08 |
| 392.34 | 4.94 | 4.94 |
| 343.47 | 4.19 | 4.19 |
| 382.34 | 5.49 | 5.49 |
| 395.57 | 5.91 | 5.91 |
| 313.45 | 4.18 | 4.18 |
| 327.47 | 4.49 | 4.49 |
| 382.34 | 5.49 | 5.49 |
| 347.89 | 4.83 | 4.83 |
| 327.47 | 4.49 | 4.49 |
| 392.34 | 4.94 | 4.94 |