Basic Information
ID: ALA4380534
Type: Binding
Description: Selectivity index, ratio of IC50 for wild-type human partial length ULK1 (M1 to T309 residues) expressed in mammalian expression system by Kinomescan method to IC50 for inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with enzyme for 15 mins followed by substrate addition and further incubated for 30 mins in presence of 10 uM of ATP by TR-FRET assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Unchecked(ALA612545)
Document: ALA4376867
Selectivity index, ratio of IC50 for wild-type human partial length ULK1 (M1 to T309 residues) expressed in mammalian expression system by Kinomescan method to IC50 for inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with enzyme for 15 mins followed by substrate addition and further incubated for 30 mins in presence of 10 uM of ATP by TR-FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4380534
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 553.59 | 4.38 | 4.38 |