Basic Information
ID: ALA4386543
Type: Functional
Description: Antitumor activity against human GIST430 cells harboring c-KIT exon 11 primary in-frame V560-L576 deletion mutant and exon 13 heterozygous secondary missense V654A mutant xenografted in NOD-SCID mouse assessed as tumor growth inhibition at 40 mg/kg, po administered for 2 weeks with 2 days rest after day 5 and measured thrice per week up to 21 days during compound dosing
Organism: Homo sapiens
Cell type: GIST430
Activity Charts
Bioactivity
Activity Types for Assay ALA4386543
TGI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 398.48 | 3.33 | 3.33 |