Basic Information
ID: ALA4386804
Type: Functional
Description: Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Muscarinic acetylcholine receptor M4(ALA1821)
Document: ALA4385625
Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4386804
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 397.89 | 3.91 | 3.91 |
| 376.49 | 4.17 | 4.17 |
| 399.45 | 3.22 | 3.22 |
| 321.79 | 2.38 | 2.38 |
| 445.44 | 2.70 | 2.70 |
| 364.43 | 2.13 | 2.13 |
| 363.45 | 2.73 | 2.73 |
| 414.44 | 2.73 | 2.73 |
| 414.44 | 2.73 | 2.73 |
| 363.45 | 3.25 | 3.25 |
| 363.45 | 2.73 | 2.73 |
| 469.47 | 3.06 | 3.06 |
| 495.92 | 3.83 | 3.83 |
| 381.46 | 3.08 | 3.08 |
| 397.89 | 3.39 | 3.39 |
| 442.94 | 2.51 | 2.51 |
| 376.49 | 3.65 | 3.65 |
| 367.43 | 2.77 | 2.77 |
| 378.46 | 2.44 | 2.44 |
| 462.46 | 2.57 | 2.57 |
| 367.43 | 2.77 | 2.77 |
| 462.37 | 3.46 | 3.46 |
| 424.49 | 2.02 | 2.02 |
| 428.47 | 3.04 | 3.04 |
| 362.46 | 3.86 | 3.86 |
| 377.47 | 3.04 | 3.04 |
| 287.35 | 1.73 | 1.73 |
| 434.53 | 2.43 | 2.43 |
| 428.91 | 2.21 | 2.21 |
| 366.45 | 3.38 | 3.38 |
| 335.82 | 2.69 | 2.69 |
| 364.43 | 2.13 | 2.13 |
| 362.46 | 3.34 | 3.34 |
| 286.36 | 2.33 | 2.33 |
| 363.45 | 2.73 | 2.73 |
| 411.92 | 3.69 | 3.69 |
| 483.50 | 3.37 | 3.37 |
| 377.47 | 3.04 | 3.04 |
| 377.47 | 3.56 | 3.56 |
| 440.53 | 2.44 | 2.44 |