Basic Information
ID: ALA4388124
Type: ADME
Description: Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured after 45 mins in presence of biotinylated-NAD+ by ELISA
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4388124
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.32 | 3.66 | 3.66 |
| 529.97 | 4.48 | 4.48 |
| 340.43 | 1.98 | 1.98 |
| 340.43 | 1.98 | 1.98 |
| 351.41 | 2.31 | 2.31 |
| 339.44 | 3.04 | 3.04 |
| 342.40 | 1.18 | 1.18 |
| 416.47 | 2.28 | 2.28 |
| 358.47 | 1.89 | 1.89 |
| 337.42 | 2.58 | 2.58 |
| 358.47 | 1.89 | 1.89 |
| 340.43 | 1.98 | 1.98 |
| 336.44 | 2.25 | 2.25 |
| 376.41 | 2.23 | 2.23 |
| 463.37 | 2.83 | 2.83 |
| 342.40 | 1.18 | 1.18 |
| 337.42 | 2.95 | 2.95 |
| 376.41 | 2.23 | 2.23 |
| 336.44 | 2.61 | 2.61 |
| 428.92 | 2.18 | 2.18 |
| 350.42 | 1.89 | 1.89 |
| 414.94 | 2.65 | 2.65 |
| 358.47 | 1.89 | 1.89 |
| 394.48 | 1.53 | 1.53 |
| 337.42 | 2.67 | 2.67 |
| 430.46 | 1.80 | 1.80 |
| 350.42 | 2.14 | 2.14 |
| 374.47 | 0.91 | 0.91 |
| 398.48 | 2.14 | 2.14 |
| 351.41 | 2.11 | 2.11 |
| 412.47 | 1.66 | 1.66 |
| 380.49 | 2.00 | 2.00 |
| 354.45 | 2.37 | 2.37 |
| 449.38 | 3.31 | 3.31 |