Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured after...

Basic Information

ID: ALA4388124

Type: ADME

Description: Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured after 45 mins in presence of biotinylated-NAD+ by ELISA

Format: BAO_0000019

Organism: Homo sapiens

Target: Poly [ADP-ribose] polymerase-1(ALA3105)

Document: ALA4387706

Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured after 45 mins in presence of biotinylated-NAD+ by ELISA: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4388124

IC50

Total(34)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
312.32	3.66	3.66
529.97	4.48	4.48
340.43	1.98	1.98
340.43	1.98	1.98
351.41	2.31	2.31
339.44	3.04	3.04
342.40	1.18	1.18
416.47	2.28	2.28
358.47	1.89	1.89
337.42	2.58	2.58
358.47	1.89	1.89
340.43	1.98	1.98
336.44	2.25	2.25
376.41	2.23	2.23
463.37	2.83	2.83
342.40	1.18	1.18
337.42	2.95	2.95
376.41	2.23	2.23
336.44	2.61	2.61
428.92	2.18	2.18
350.42	1.89	1.89
414.94	2.65	2.65
358.47	1.89	1.89
394.48	1.53	1.53
337.42	2.67	2.67
430.46	1.80	1.80
350.42	2.14	2.14
374.47	0.91	0.91
398.48	2.14	2.14
351.41	2.11	2.11
412.47	1.66	1.66
380.49	2.00	2.00
354.45	2.37	2.37
449.38	3.31	3.31