Basic Information
ID: ALA4388508
Type: Functional
Description: Antitumor activity against human NCI-H2228 cells harboring EML4-fused ALK variant xenografted in SCID Beige nude mouse assessed as tumor growth inhibition at 10 mg/kg, po administered once daily for 14 days measured twice per week for 21 days during compound dosing relative to control
Format: BAO_0000218
Organism: Homo sapiens
Cell type: NCI-H2228
Target: NCI-H2228(ALA1075536)
Document: ALA4387718
Antitumor activity against human NCI-H2228 cells harboring EML4-fused ALK variant xenografted in SCID Beige nude mouse assessed as tumor growth inhibition at 10 mg/kg, po administered once daily for 14 days measured twice per week for 21 days during compound dosing relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4388508
TGI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 558.15 | 6.36 | 6.36 |
| 533.11 | 5.58 | 5.58 |