Basic Information
ID: ALA4390077
Type: Binding
Description: Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current by measuring maximum efficacy of acetylcholine at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method (Rvb = 339%)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4390077
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 369.83 | 4.99 | 4.99 |