Basic Information
ID: ALA4390079
Type: Binding
Description: Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: Neuronal acetylcholine receptor protein alpha-7 subunit(ALA2492)
Document: ALA4387746
Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4390079
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 382.81 | 4.45 | 4.45 |
| 337.81 | 4.54 | 4.54 |
| 372.26 | 5.20 | 5.20 |
| 365.86 | 5.11 | 5.11 |
| 383.90 | 5.27 | 5.27 |
| 340.79 | 5.10 | 5.10 |
| 390.25 | 5.34 | 5.34 |
| 353.81 | 4.25 | 4.25 |
| 369.83 | 4.99 | 4.99 |
| 421.81 | 5.44 | 5.44 |
| 355.80 | 4.68 | 4.68 |
| 343.84 | 4.61 | 4.61 |
| 405.81 | 5.56 | 5.56 |
| 357.24 | 5.62 | 5.62 |
| 394.86 | 4.50 | 4.50 |
| 351.84 | 4.85 | 4.85 |
| 369.83 | 4.99 | 4.99 |
| 321.36 | 4.03 | 4.03 |
| 335.38 | 4.34 | 4.34 |
| 367.84 | 4.55 | 4.55 |
| 390.25 | 5.34 | 5.34 |
| 354.81 | 5.29 | 5.29 |
| 369.83 | 4.99 | 4.99 |
| 390.25 | 5.34 | 5.34 |
| 338.80 | 3.94 | 3.94 |
| 336.82 | 5.27 | 5.27 |
| 369.83 | 4.99 | 4.99 |
| 355.80 | 4.68 | 4.68 |
| 367.84 | 4.55 | 4.55 |
| 355.80 | 4.68 | 4.68 |
| 327.77 | 4.14 | 4.14 |
| 367.84 | 4.55 | 4.55 |