Basic Information
ID: ALA4392313
Type: Binding
Description: Mixed noncompetitive inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as substrate Kcat at 250 uM using varying levels of [3',5',7,9-3H]-H2folate as substrate preincubated for 10 mins before NADPH addition for 5 mins followed by substrate addition and measured after 5 mins by Lineweaver-Burk plot analysis (Rvb = 2.17 +/- 0.04 /s)
Organism: Cryptosporidium hominis
Activity Charts
Bioactivity
Activity Types for Assay ALA4392313
Kcat
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 456.37 | 5.52 | 5.52 |