Basic Information
ID: ALA4392318
Type: Binding
Description: Inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as reduction in DHFR steady state activity using [3',5',7,9-3H]-H2folate as substrate preincubated for 10 mins before NADPH addition for 5 mins followed by substrate addition and measured after 5 mins by NADPH based radiometric chemical quench assay relative to control
Organism: Cryptosporidium hominis
Activity Charts
Bioactivity
Activity Types for Assay ALA4392318
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 373.58 | 3.90 | 3.90 |
| 361.02 | 4.71 | 4.71 |
| 282.13 | 3.95 | 3.95 |
| 456.37 | 5.52 | 5.52 |
| 344.57 | 4.20 | 4.20 |
| 296.15 | 4.26 | 4.26 |