Basic Information
ID: ALA4392322
Type: Binding
Description: Inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as decrease in DHFR steady state activity at 500 uM using [3',5',7,9-3H]-H2folate as substrate preincubated for 16 hrs with DTT prior to NADPH addition and incubated for 5 mins followed by substrate addition and measured after 5 mins by NADPH based radiometric chemical quench assay relative to control
Organism: Cryptosporidium hominis
Activity Charts
Bioactivity
Activity Types for Assay ALA4392322
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 324.20 | 3.70 | 3.70 |
| 259.33 | 3.24 | 3.24 |
| 296.15 | 4.26 | 4.26 |