Basic Information
ID: ALA4392742
Type: Binding
Description: Inhibition of recombinant human N-terminal GST-tagged BRAF V600E mutant catalytic domain (416 to 766 residues) expressed in baculovirus expression system using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured after 2 hrs by filter-binding assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Serine/threonine-protein kinase B-raf(ALA5145)
Document: ALA4390702
Inhibition of recombinant human N-terminal GST-tagged BRAF V600E mutant catalytic domain (416 to 766 residues) expressed in baculovirus expression system using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured after 2 hrs by filter-binding assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4392742
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 464.83 | 5.55 | 5.55 |
| 390.42 | 3.38 | 3.38 |
| 362.39 | 3.07 | 3.07 |
| 391.43 | 3.68 | 3.68 |
| 477.87 | 5.69 | 5.69 |
| 449.82 | 5.08 | 5.08 |
| 361.40 | 3.67 | 3.67 |
| 376.42 | 3.26 | 3.26 |
| 376.42 | 3.26 | 3.26 |
| 477.87 | 5.74 | 5.74 |
| 379.39 | 3.81 | 3.81 |
| 463.84 | 5.35 | 5.35 |
| 395.85 | 4.33 | 4.33 |
| 411.46 | 4.83 | 4.83 |
| 377.40 | 3.38 | 3.38 |