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Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC50 for inhibition of Escherichia coli GroEL expressed in Escheric...

Basic Information

ID: ALA4392930

Type: Binding

Description: Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC50 for inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis

Format: BAO_0000019

Target:  Unchecked(ALA612545)

Document:  ALA4392822

Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC50 for inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
303.143.613.61
224.263.293.29
224.263.293.29
853.923.743.74
406.916.616.61
172.182.012.01
368.393.373.37
269.134.004.00
238.293.593.59
458.382.232.23
256.211.581.58
407.994.464.46
384.657.627.62
416.564.854.85
875.115.605.60
412.536.686.68
220.364.694.69
448.096.076.07
424.095.465.46
376.585.515.51
396.667.647.64
960.826.676.67
340.294.194.19
562.677.507.50
300.271.331.33
578.616.386.38
873.095.385.38
914.145.525.52
358.016.466.46