ID: ALA4392930
Type: Binding
Description: Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC50 for inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis
Format: BAO_0000019
Target: Unchecked(ALA612545)
Document: ALA4392822
Selectivity index, ratio of IC50 for inhibition of native soluble pig heart MDH to IC50 for inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis: 1
Bioactivity
Activity Types for Assay ALA4392930
Ratio IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
303.14 | 3.61 | 3.61 |
224.26 | 3.29 | 3.29 |
224.26 | 3.29 | 3.29 |
853.92 | 3.74 | 3.74 |
406.91 | 6.61 | 6.61 |
172.18 | 2.01 | 2.01 |
368.39 | 3.37 | 3.37 |
269.13 | 4.00 | 4.00 |
238.29 | 3.59 | 3.59 |
458.38 | 2.23 | 2.23 |
256.21 | 1.58 | 1.58 |
407.99 | 4.46 | 4.46 |
384.65 | 7.62 | 7.62 |
416.56 | 4.85 | 4.85 |
875.11 | 5.60 | 5.60 |
412.53 | 6.68 | 6.68 |
220.36 | 4.69 | 4.69 |
448.09 | 6.07 | 6.07 |
424.09 | 5.46 | 5.46 |
376.58 | 5.51 | 5.51 |
396.66 | 7.64 | 7.64 |
960.82 | 6.67 | 6.67 |
340.29 | 4.19 | 4.19 |
562.67 | 7.50 | 7.50 |
300.27 | 1.33 | 1.33 |
578.61 | 6.38 | 6.38 |
873.09 | 5.38 | 5.38 |
914.14 | 5.52 | 5.52 |
358.01 | 6.46 | 6.46 |