Basic Information
ID: ALA4393072
Type: Functional
Description: Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incubated for 142 secs prior to glutamate addition for 120 secs followed by L-AP4 addition and measured after 40 secs by Fluo-4 AM dye based fluorescence assay
Organism: Rattus norvegicus
Activity Charts
Bioactivity
Activity Types for Assay ALA4393072
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 432.36 | 4.51 | 4.51 |
| 432.36 | 4.51 | 4.51 |
| 473.41 | 4.68 | 4.68 |
| 433.35 | 3.90 | 3.90 |
| 431.37 | 4.24 | 4.24 |
| 449.41 | 5.44 | 5.44 |
| 434.33 | 3.30 | 3.30 |
| 464.44 | 4.07 | 4.07 |
| 473.41 | 4.82 | 4.82 |
| 451.34 | 4.04 | 4.04 |
| 433.35 | 3.90 | 3.90 |
| 432.36 | 4.71 | 4.71 |
| 488.45 | 4.62 | 4.62 |
| 446.39 | 4.72 | 4.72 |
| 431.33 | 3.65 | 3.65 |
| 432.36 | 4.51 | 4.51 |
| 432.36 | 3.43 | 3.43 |
| 449.41 | 4.37 | 4.37 |
| 449.43 | 5.31 | 5.31 |
| 433.35 | 2.83 | 2.83 |
| 451.34 | 4.04 | 4.04 |
| 421.31 | 4.03 | 4.03 |
| 451.40 | 4.16 | 4.16 |
| 443.38 | 5.38 | 5.38 |
| 432.36 | 4.51 | 4.51 |
| 446.39 | 4.72 | 4.72 |
| 444.37 | 4.78 | 4.78 |
| 404.31 | 3.29 | 3.29 |
| 421.31 | 4.03 | 4.03 |
| 439.30 | 4.17 | 4.17 |
| 483.41 | 3.95 | 3.95 |
| 489.44 | 4.02 | 4.02 |
| 404.31 | 3.29 | 3.29 |
| 433.35 | 3.90 | 3.90 |
| 443.38 | 5.38 | 5.38 |
| 435.40 | 4.92 | 4.92 |
| 482.42 | 4.56 | 4.56 |
| 453.28 | 4.20 | 4.20 |
| 417.30 | 3.61 | 3.61 |