Assay Report Card

Basic Information

ID: ALA4393073

Type: Functional

Description: Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as minimum L-AP4 response by measuring reduction in calcium mobilization incubated for 142 secs prior to glutamate addition for 120 secs followed by L-AP4 addition and measured after 40 secs by Fluo-4 AM dye based fluorescence assay relative to L-AP4 alone

Organism: Rattus norvegicus

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
432.364.514.51
432.364.514.51
473.414.684.68
433.353.903.90
431.374.244.24
449.415.445.44
434.333.303.30
473.414.824.82
451.344.044.04
433.353.903.90
432.364.714.71
446.394.724.72
432.364.514.51
432.363.433.43
449.414.374.37
449.435.315.31
451.404.164.16
432.364.514.51
444.374.784.78
404.313.293.29
433.353.903.90
443.385.385.38