Basic Information
ID: ALA4394741
Type: Binding
Description: Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack complex formation preincubated for 15 mins followed by zymosan stimulation and measured after 40 mins by ELISA
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Complement factor D(ALA2176771)
Document: ALA4393676
Inhibition of FD-mediated alternative complementation pathway in 50% human whole blood assessed as reduction in zymosan-induced membrane-attack complex formation preincubated for 15 mins followed by zymosan stimulation and measured after 40 mins by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4394741
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 356.47 | 4.62 | 4.62 |
| 407.47 | 3.04 | 3.04 |
| 437.52 | 3.03 | 3.03 |
| 434.54 | 4.37 | 4.37 |
| 346.43 | 4.05 | 4.05 |
| 347.41 | 4.02 | 4.02 |
| 347.41 | 4.02 | 4.02 |
| 374.44 | 3.78 | 3.78 |
| 360.41 | 3.69 | 3.69 |
| 421.49 | 3.70 | 3.70 |
| 361.44 | 4.58 | 4.58 |
| 456.34 | 4.31 | 4.31 |
| 384.44 | 3.17 | 3.17 |
| 391.47 | 3.94 | 3.94 |
| 377.44 | 3.55 | 3.55 |
| 361.40 | 3.09 | 3.09 |
| 435.52 | 3.78 | 3.78 |