Inhibition of recombinant N-terminal His6-tagged Mycobacterium tuberculosis H37Rv IMPDH expressed in Escherichia coli BL21 (DE3) cells assessed as red...

Basic Information

ID: ALA4395370

Type: Binding

Description: Inhibition of recombinant N-terminal His6-tagged Mycobacterium tuberculosis H37Rv IMPDH expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of NAD+ to NADH using IMP and NAD+ as substrate treated 1 min after substrate incubation with enzyme by UV-visible spectrophotometry

Format: BAO_0000219

Organism: Mycobacterium tuberculosis H37Rv

Target: Unchecked(ALA612545)

Document: ALA4393693

Inhibition of recombinant N-terminal His6-tagged Mycobacterium tuberculosis H37Rv IMPDH expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of NAD+ to NADH using IMP and NAD+ as substrate treated 1 min after substrate incubation with enzyme by UV-visible spectrophotometry: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4395370

IC50

Total(49)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
386.52	3.25	3.25
361.47	2.21	2.21
475.91	3.33	3.33
406.47	2.25	2.25
448.91	3.57	3.57
381.46	2.38	2.38
401.53	3.04	3.04
425.51	2.32	2.32
386.52	3.25	3.25
319.39	1.04	1.04
471.45	2.20	2.20
430.92	3.43	3.43
401.53	3.08	3.08
426.45	2.29	2.29
454.51	2.89	2.89
401.53	3.04	3.04
411.48	2.02	2.02
411.48	2.88	2.88
401.53	2.96	2.96
421.48	2.64	2.64
387.51	2.65	2.65
445.41	1.76	1.76
406.47	2.25	2.25
410.50	2.45	2.45
455.54	2.33	2.33
444.94	3.74	3.74
456.55	2.67	2.67
465.36	4.08	4.08
440.48	2.50	2.50
401.53	3.04	3.04
413.47	2.45	2.45
455.50	2.99	2.99
464.47	3.79	3.79
333.41	1.43	1.43
444.94	3.74	3.74
454.51	2.94	2.94
401.53	2.89	2.89
440.53	2.46	2.46
498.91	4.45	4.45
401.53	3.04	3.04
420.49	2.18	2.18
401.53	3.08	3.08
409.51	2.62	2.62
471.54	2.41	2.41
440.48	2.22	2.22
424.53	2.76	2.76
361.47	2.11	2.11
454.51	2.89	2.89
459.57	2.39	2.39