Basic Information
ID: ALA4397903
Type: Binding
Description: Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production at 1 uM preincubated for 1 hr followed by LPS stimulation and measured after 18 to 20 hrs by ELISA relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4397903
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 448.56 | 4.67 | 4.67 |
| 441.53 | 4.95 | 4.95 |
| 432.56 | 5.49 | 5.49 |
| 408.50 | 3.89 | 3.89 |
| 392.50 | 4.57 | 4.57 |