Basic Information
ID: ALA4397905
Type: Binding
Description: Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 to 20 hrs by ELISA
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4397905
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 418.54 | 4.96 | 4.96 |
| 364.45 | 3.87 | 3.87 |
| 378.47 | 4.18 | 4.18 |
| 404.51 | 4.65 | 4.65 |
| 378.47 | 4.26 | 4.26 |
| 382.44 | 4.01 | 4.01 |