Basic Information
ID: ALA4400738
Type: Binding
Description: Poison activity at recombinant human topoisomerase-2 assessed as stabilization of covalent topo-2-DNA cleavage complex by measuring linear DNA formation at 10 uM using supercoiled pBR322 DNA as substrate after 60 mins by agarose gel electrophoresis method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4400738
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 393.47 | 4.51 | 4.51 |
| 440.57 | 4.74 | 4.74 |
| 353.45 | 3.33 | 3.33 |
| 410.54 | 4.73 | 4.73 |
| 391.32 | 5.24 | 5.24 |
| 386.90 | 4.59 | 4.59 |
| 380.51 | 4.72 | 4.72 |
| 357.87 | 3.98 | 3.98 |
| 352.46 | 3.94 | 3.94 |
| 381.50 | 4.11 | 4.11 |
| 385.92 | 4.76 | 4.76 |
| 412.51 | 3.96 | 3.96 |
| 351.48 | 4.11 | 4.11 |
| 416.93 | 4.60 | 4.60 |
| 414.96 | 5.37 | 5.37 |
| 419.38 | 6.02 | 6.02 |
| 411.53 | 4.12 | 4.12 |
| 444.98 | 5.38 | 5.38 |
| 323.42 | 3.33 | 3.33 |