Basic Information
ID: ALA4401384
Type: Binding
Description: Irreversible inhibition of recombinant human FLT3 D835Y mutant (571 to 993 residues) expressed in baculovirus expression system at 0.1 uM preincubated for 5 to 30 mins followed by myelobasic protein addition measured after 120 mins in presence of ATP by ADP-Glo assay relative to control
Format: BAO_0000019
Organism: Homo sapiens
Target: Tyrosine-protein kinase receptor FLT3(ALA1974)
Document: ALA4400537
Irreversible inhibition of recombinant human FLT3 D835Y mutant (571 to 993 residues) expressed in baculovirus expression system at 0.1 uM preincubated for 5 to 30 mins followed by myelobasic protein addition measured after 120 mins in presence of ATP by ADP-Glo assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4401384
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 398.48 | 3.33 | 3.33 |
| 210.24 | 2.51 | 2.51 |
| 267.29 | 2.47 | 2.47 |
| 378.38 | 1.03 | 1.03 |
| 277.28 | 2.08 | 2.08 |
| 279.30 | 2.63 | 2.63 |
| 443.55 | 3.92 | 3.92 |
| 349.40 | 3.52 | 3.52 |
| 346.18 | 2.84 | 2.84 |
| 471.99 | 3.37 | 3.37 |
| 383.84 | 3.74 | 3.74 |
| 399.48 | 3.33 | 3.33 |
| 292.35 | 3.56 | 3.56 |
| 361.41 | 3.69 | 3.69 |
| 383.84 | 3.74 | 3.74 |
| 361.41 | 3.69 | 3.69 |
| 301.73 | 2.68 | 2.68 |
| 281.32 | 2.86 | 2.86 |
| 363.43 | 3.91 | 3.91 |
| 359.39 | 3.14 | 3.14 |
| 487.63 | 2.96 | 2.96 |
| 399.48 | 3.33 | 3.33 |
| 363.43 | 3.91 | 3.91 |
| 359.39 | 3.14 | 3.14 |
| 315.35 | 2.39 | 2.39 |
| 285.28 | 2.42 | 2.42 |
| 485.61 | 3.08 | 3.08 |
| 317.37 | 2.27 | 2.27 |
| 437.54 | 3.15 | 3.15 |
| 397.46 | 3.45 | 3.45 |
| 349.40 | 3.52 | 3.52 |
| 397.46 | 3.45 | 3.45 |