Basic Information
ID: ALA4402146
Type: Binding
Description: Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by HTRF assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Tyrosine-protein kinase JAK2(ALA2971)
Document: ALA4400567
Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4402146
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.38 | 1.54 | 1.54 |
| 366.43 | 1.47 | 1.47 |
| 364.21 | 1.25 | 1.25 |
| 380.46 | 1.54 | 1.54 |
| 378.23 | 1.32 | 1.32 |
| 388.44 | 2.29 | 2.29 |
| 380.41 | 0.97 | 0.97 |
| 374.41 | 2.48 | 2.48 |
| 459.51 | 1.82 | 1.82 |
| 410.48 | 1.39 | 1.39 |
| 366.43 | 1.47 | 1.47 |
| 432.49 | 2.21 | 2.21 |
| 345.37 | 2.24 | 2.24 |
| 424.51 | 1.46 | 1.46 |
| 364.21 | 1.25 | 1.25 |
| 437.51 | 1.00 | 1.00 |
| 402.42 | 1.79 | 1.79 |
| 365.24 | 1.60 | 1.60 |
| 397.49 | 0.84 | 0.84 |
| 394.44 | 1.05 | 1.05 |
| 398.21 | 1.36 | 1.36 |
| 396.46 | 1.00 | 1.00 |
| 366.39 | 0.58 | 0.58 |
| 352.40 | 1.08 | 1.08 |
| 378.23 | 1.32 | 1.32 |
| 459.51 | 1.82 | 1.82 |
| 365.24 | 1.60 | 1.60 |
| 351.21 | 1.52 | 1.52 |
| 351.21 | 1.52 | 1.52 |
| 373.21 | 2.34 | 2.34 |
| 423.48 | 1.11 | 1.11 |
| 432.49 | 2.21 | 2.21 |