Basic Information
ID: ALA4402446
Type: Binding
Description: Inhibition of TYK2 JH2 domain in human whole blood assessed as decrease in IFNalpha/IL2-induced STAT phosphorylation preincubated for 1 hr followed by IFNalpha/IL2 stimulation and measured after 15 mins by fluorescence assay
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Tyrosine-protein kinase TYK2(ALA3553)
Document: ALA4400582
Inhibition of TYK2 JH2 domain in human whole blood assessed as decrease in IFNalpha/IL2-induced STAT phosphorylation preincubated for 1 hr followed by IFNalpha/IL2 stimulation and measured after 15 mins by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4402446
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 350.43 | 3.02 | 3.02 |
| 473.54 | 2.79 | 2.79 |
| 434.44 | 2.09 | 2.09 |
| 435.42 | 1.49 | 1.49 |
| 418.46 | 2.20 | 2.20 |
| 430.47 | 2.34 | 2.34 |
| 452.43 | 2.04 | 2.04 |
| 449.45 | 1.60 | 1.60 |
| 431.46 | 1.66 | 1.66 |
| 440.47 | 2.43 | 2.43 |
| 433.48 | 1.60 | 1.60 |
| 451.47 | 1.55 | 1.55 |
| 416.45 | 1.95 | 1.95 |
| 434.44 | 2.09 | 2.09 |
| 353.39 | 1.11 | 1.11 |
| 434.44 | 1.90 | 1.90 |
| 462.51 | 1.81 | 1.81 |
| 379.42 | 1.90 | 1.90 |
| 434.44 | 2.09 | 2.09 |
| 452.43 | 2.04 | 2.04 |
| 434.44 | 2.09 | 2.09 |
| 416.45 | 1.95 | 1.95 |