Basic Information
ID: ALA4403863
Type: Binding
Description: Inhibition of human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formation at 10 uM using LRRKtide as substrate measured after 1 hr in presence of ATP by Adapta assay relative to control
Format: BAO_0000019
Organism: Homo sapiens
Target: Leucine-rich repeat serine/threonine-protein kinase 2(ALA1075104)
Document: ALA4402549
Inhibition of human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system assessed as reduction in ADP formation at 10 uM using LRRKtide as substrate measured after 1 hr in presence of ATP by Adapta assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4403863
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 272.30 | 3.69 | 3.69 |
| 373.87 | 4.04 | 4.04 |
| 353.45 | 3.69 | 3.69 |
| 407.42 | 4.40 | 4.40 |
| 418.32 | 4.15 | 4.15 |
| 381.50 | 4.51 | 4.51 |
| 383.47 | 3.78 | 3.78 |
| 357.41 | 3.52 | 3.52 |
| 369.45 | 3.39 | 3.39 |
| 397.50 | 4.17 | 4.17 |
| 306.75 | 4.34 | 4.34 |
| 339.42 | 3.39 | 3.39 |