Basic Information
ID: ALA4405142
Type: Binding
Description: Inhibition of human PI3Kalpha assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex at 1 uM using PIP2 as substrate measured after 30 mins in presence of ATP by HTRF assay relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: PI3-kinase p110-alpha subunit(ALA4005)
Document: ALA4402587
Inhibition of human PI3Kalpha assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex at 1 uM using PIP2 as substrate measured after 30 mins in presence of ATP by HTRF assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4405142
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 302.37 | 2.58 | 2.58 |
| 348.36 | 2.98 | 2.98 |
| 568.62 | 3.80 | 3.80 |
| 562.59 | 3.74 | 3.74 |
| 589.64 | 5.01 | 5.01 |
| 582.65 | 3.48 | 3.48 |
| 551.57 | 3.94 | 3.94 |
| 546.59 | 4.33 | 4.33 |
| 532.56 | 4.40 | 4.40 |
| 575.63 | 4.02 | 4.02 |