Basic Information
ID: ALA4405653
Type: Binding
Description: Selectivity index, ratio of IC50 for inhibition of recombinant C-terminal His-fusion tagged and N-terminal Streptavidin2-tagged human HDAC8 (1 to 377 residues) expressed in insect cells using fluorogenic peptide p53 residues 379-382 (RHK(Ac)K(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay to IC50 for inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1125 residues) expressed in baculovirus infected insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4405653
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 611.61 | 4.86 | 4.86 |
| 575.63 | 4.23 | 4.23 |
| 540.63 | 4.11 | 4.11 |
| 586.06 | 4.29 | 4.29 |
| 585.07 | 5.01 | 5.01 |
| 629.60 | 4.94 | 4.94 |
| 575.63 | 3.68 | 3.68 |
| 601.67 | 4.80 | 4.80 |
| 575.63 | 4.23 | 4.23 |
| 572.03 | 4.10 | 4.10 |
| 550.62 | 4.36 | 4.36 |
| 562.59 | 3.12 | 3.12 |
| 576.62 | 3.51 | 3.51 |
| 571.04 | 4.71 | 4.71 |
| 590.60 | 2.43 | 2.43 |
| 515.62 | 4.24 | 4.24 |
| 561.61 | 3.84 | 3.84 |
| 541.62 | 3.59 | 3.59 |
| 541.62 | 3.38 | 3.38 |
| 561.61 | 3.92 | 3.92 |
| 564.57 | 1.91 | 1.91 |